Friday night Pandemic Watch - Swine Flu coming to you?

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Postby chiggerbit » Mon May 18, 2009 1:09 pm

Another case where the headline exaggerates? I would have said that WHO took the theory rather seriously. Not saying their result is right, but at least they seriously considered the possibility.

http://timesofindia.indiatimes.com/Indi ... 536377.cms

H1N1 flu: WHO rubbishes lab test gone wrong theory
16 May 2009, 0328 hrs IST, Kounteya Sinha, TNN

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NEW DELHI: The World Health Organisation on Thursday debunked the theory that

the deadly H1N1 swine flu virus was the result of a lab test
gone awfully wrong.

The theory was recently floated by a renowned Australian virologist Adrian Gibbs who said that the new flu virus may have been created in a laboratory having accidentally evolved in eggs that scientists use to grow viruses in and drug makers use to make vaccines with.

WHO's assistant director-general Dr Keiji Fukuda said, "Based on our evaluation, the conclusion is that the hypothesis does not really stand up to scrutiny. The evidence actually suggests that this is a naturally occurring virus and not a laboratory derived virus."

Dr Fukuda said the WHO made the conclusion after a series of discussions with scientists in its five collaborating influenza centres, virologists across the world, experts from the Food and Agriculture Organization (FAO) and the World Organization for Animal Health (OIE).

According to WHO, all the scientists were asked to look at the evidence and then provide their opinion on whether it was a credible hypothesis or not. "We took the hypothesis very seriously, because of the nature of the hypothesis and because of the credible nature of the scientist. Because we are dealing with an influenza virus that is new, which originates from swine, we contacted the FAO and OIE," Dr Fukuda said.

Gibbs had said that genetic markers suggested that the combination of genes in the virus was not a natural event.

Dr Gibbs, who had studied the gene sequences of the swine flu virus posted on public data banks, argued that it must have been grown in eggs, the medium used in vaccine laboratories.

He reached that conclusion, he said, because the new virus was not closely related to known ones and because it had more of the amino acid lysine and more mutations than typical strains of swine flu.

Scientists at Imperial College, London, recently found that the H1N1 flu virus presently causing havoc won't be as catastrophic as the Spanish flu outbreak of 1918 that killed over 50 million people.

However, the virus does have a full fledged pandemic potential and appears to be as clinically severe as the H2N2 virus responsible for the 1957 Asian flu pandemic, in which four million people perished.

The 1957 pandemic started in China and came in two waves -- the first wave mostly hit children while the second mostly affected the elderly. In total, the pandemic caused about four million deaths globally.

Genetic analysis of the present virus has also revealed that the 2009 virus is more transmissible than seasonal flu.

The researchers estimate that the new strain is fatal in around four in every 1,000 cases.
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Postby chiggerbit » Mon May 18, 2009 1:33 pm

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Postby chiggerbit » Tue May 19, 2009 2:08 pm

Toddler dead in NY, possible swine flu victim. The name looks Spanish/Latino. I noticed a comment of racist nature on the Marshall County, Iowa's newspaper's last article I could find about the flu there. I think the flu has died down there. The commenter was blaming the Latinos for spreading the flu, and I think he had said something about looking at who had come down with the virus to see that he was right. At first I dismissed his comment as racism, and I'm not changing my mind on that point. But I got to wondering if more of the victims there were actually Latino, which reminded me of how the flu was more deadly for the Mexicans than it's been for Americans in general, and so now I'm looking to see if there could possibly be a genetic component to this in some way.

Wisconsin and Illinois are hot spots to watch.

The article about the NY toddler:

http://www.chicagotribune.com/topic/ny- ... 1742.story
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Postby chiggerbit » Tue May 19, 2009 2:14 pm

Lodi, Wisconsin:

http://www.chicagotribune.com/news/chi- ... 7451.story

"....When the school district confirmed a seventh student had the flu, officials consulted with the state Division of Health and decided to close the schools.



District officials say 26 percent of the elementary school population was absent Monday. The normal rate is about 5 percent."
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Postby chiggerbit » Tue May 19, 2009 2:18 pm

Illinois is testing only the most serious cases now, so "confirmed" numbers will be no indication of how many swine flu cases there are out there:

http://www.chicagotribune.com/news/chi- ... 5647.story

"....Total: 707 confirmed."
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Postby chiggerbit » Wed May 20, 2009 12:00 am

Wisconsin has 765 confirmed cases, but the flu seems to have pretty much run its course, as there are no probables at this time:

http://www.wrex.com/Global/story.asp?S=10386758
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Postby lightningBugout » Wed May 20, 2009 12:39 am

Survey Finds Link Between Obesity and Flu Severity

By David Brown and Robin Shulman
Washington Post Staff Writers
Wednesday, May 20, 2009


A survey of people hospitalized because of swine flu in California has raised the possibility that obesity is as much of a risk factor for serious complications from the flu as diabetes, heart disease and pregnancy, all known to raise a person's risk.

In all, about two-thirds of the California patients had some underlying medical condition, according to a report yesterday in the weekly bulletin of the Centers for Disease Control and Prevention.

Nationwide, 47 states and the District have reported 5,469 cases and six deaths since the start of the outbreak in late April, according to the CDC's count. Yesterday, officials in Missouri reported a seventh U.S. death -- that of a 44-year-old man who had no underlying medical problems, wire services reported.

"We were surprised by the frequency of obesity among the severe cases that we've been tracking," said Anne Schuchat, one of the CDC epidemiologists managing the outbreak. She said scientists are "looking into" the possibility that obese people should be at the head of the line along with other high-risk groups if a swine flu vaccine becomes available.

Other studies have shown that pregnant women are also at higher risk for serious influenza infection, especially in the third trimester, when the fetus and womb compress the lower parts of the lungs. This makes it harder to breathe deeply and cough forcefully; it may also alter blood flow in the chest. A similar thing may be occurring in severely overweight people, some experts speculated.

The average age of the 30 Californians hospitalized for swine flu was 27.5 years. Nearly three-quarters were women, and 65 percent were Hispanic. Half lived in two counties bordering Mexico.

Of the 30 people, 11 had a lung ailment such as asthma or emphysema, six had an immune disorder, five had heart disease, five were pregnant, four had diabetes and four were obese.

In New York, Mayor Michael R. Bloomberg (I) said officials were investigating whether 16-month-old Jonathan Castillo, who died with a high fever Monday night at a Queens hospital, had contracted the H1N1 virus. The toddler's 3-year-old sibling was treated for flulike symptoms and released.

The mayor said lack of health insurance or immigration status should not deter people who feel sick from seeking attention.

"Whether you have health insurance coverage or your immigration status is in question, it doesn't matter," Bloomberg said. "We will not ask about that."

The mayor also said four inmates at a Rikers Island jail had been confirmed to have the H1N1 virus and four more are likely to have it.

The union representing the city's correctional officers criticized the response to the swine flu outbreak among inmates and filed a letter of protest with the state Labor Department.

"If I had to design a place where you could put people who were sick and get as many people sick as possible, it's the New York City jail," said Richard J. Koehler, a lawyer for the Correction Officers' Benevolent Association.

Shulman reported from New York.
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Postby Col. Quisp » Wed May 20, 2009 2:55 am

Thanks, LBO. Frightening! And now from my favorite pandemic watcher, Henry Niman, M.D.


Transmission of Swine H1N1 In Japan Signals Phase 6
Recombinomics Commentary 14:46
May 18, 2009
Japan's four earlier suspected swine flu cases came from travelers inbound from North America, but this new bout appears to be wholly domestic. Most of the cases involve teenagers - the first confirmed infected on Saturday were high-school students on a volleyball team - but those sick with the new strain of flu now range from as young as 5 years old to 60. "It circulated silently without anybody thinking of it," says Peter Cordingley, spokesman for the WHO in Manila. "The virus is highly transmittable and signs of it breaking out of a contained area into the greater community must be watched and taken very seriously."

The above comments on community transmission of H1N1 in Japan (see updated map) again indicate that the pandemic is at phase 6. Early definitions of pandemic phases used sustained transmission as the definition of phase 6. However, the new definition used sustained transmission as the definition of phase 4, while phase 5 represent transmission in a region, and phase 6 was transmission worldwide.

Swine H1N1 has been transmitting worldwide for over a month. Testing outside of North America was largely limited to travelers from North America, but H1N1 was seeding prior to the enhance surveillance at airports, and transmission would have been largely undetected.

The levels in the United States (see updated map) are approaching the reported levels in Mexico, and travel from the US would increase seeding. However, these increases would also be prior to enhanced surveillance at airports. However, such testing is destined to fail, because travelers infected within a day or two of travel would not be detected. Similarly, as many as 1/3 of cases have no fever.

Although the CDC estimated that the number of true cases in the US was 100,000, that estimate is likely to be 1-2 orders of magnitude too low. Surveillance in the US detects about 0.1% of true cases, so the 1500 cases in the CDC weekly report would represent 1.5 million cases in the US alone, and this estimate may be low because many cases are mild, and those in regions not reported to have high levels are not tested.

Nationwide, the number of confirmed cases of swine H1N1 (including cases that are influenza A positive and non-typable) is close to the level reported for H3N2 for the entire season. The number of swine H1N1 cases is rapidly increasing, and in week 18 was almost 3 times the level of influenza A (1097 vs 401).

Thus, the widespread transmission in North America (Mexico, US, and Canada) insures worldwide transmission. Community transmission has already been reported in Scotland, and now there is confirmed transmission in Japan, leaving no doubt that the spread in North America has been extended to Europe and Asia.

The raising of the pandemic level to 6 is long overdue.
http://www.recombinomics.com/News/05180901/Swine_H1N1_Japan_6.html
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Postby Col. Quisp » Wed May 20, 2009 2:57 am

And here's Niman's latest article:

Suspect Swine H1N1 Toddler Death in NY Raises Concerns
Recombinomics Commentary 17:02
May 19, 2009
A medical examiner will determine if the 16-month-old boy who died shortly after arriving at Elmhurst Hospital in Queens is the second death from swine flu in New York City.

Family members say the boy was turning blue as they rushed him to the hospital.

The above comments on a suspect swine flu fatality in Queens, New York raise additional pandemic concerns. The number of confirmed and suspect cases in Queens has been high (see updated map), leading to more the a dozen school closings, due in part to the high number of students with flu like symptoms, as well as the confirmed swine H1N1 death of an assistant principal.

Yesterday, the suspect toddler developed a fever in the morning, was eating in the afternoon, and was unresponsive by evening, when he was rushed to the hospital and died. The sudden death, coupled with rapid development of cyanosis, are classic symptoms associated with fatal influenza cases in 1918.

In 1918 an H1N1 swine flu recombined with an H1N1 seasonal flu that led to 20-50 million fatalities, as the virus spread world wide and affected approximately 1/3 of the population. That outbreak began as mild disease in the spring and most of the fatalities were associated with outbreaks in the fall of 1918 and 1919. There were multiple waves during the outbreak, raising concerns of a similar scenario in 2009.

An efficiently transmitted swine H1N1 in the human population has not been reported since 1918, Although WHO has not yet raised the pandemic phase from 5 to 6, the sustained transmission in North America, combined with reports of community spread in Europe and Asia leaves little doubt that the 2009 pandemic has begun.

The evolution of the H1N1 is being closely monitored by sequencing labs across the world, and most isolates to date are closely related. However, the presence of avian PB2 raises concerns that the frequency of cases will not decline in the summer in the northern hemisphere, because the avian PB2 is optimal at 41 C, which would lead to efficient transmission in the summer. Moreover, the seasonal flu has the mammalian version of PB2, which has optimal activity at 34 C. However, the swine H1N1 transmitting in the summer hemisphere may acquire E627K, leading to a virus efficiently transmitting in the winter aso.

Similarly, swine H1N1 in the southern hemisphere may acquire H274Y, leading to Tamflu resistance, which could complicate treatment of the more severe cases, which may involve previously healthy young adults. Another H1N1 death (44M) was just reported in St. Louis, MO.

The strong parallels between 1918 and 2009 continue to cause concern.
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Postby chiggerbit » Wed May 20, 2009 7:59 am

Yesterday, the suspect toddler developed a fever in the morning, was eating in the afternoon, and was unresponsive by evening, when he was rushed to the hospital and died.


What worries me is the belief I've heard from family and friends that this flu has been over-hyped. It needs to be taken seriously, especially by people who have other conditions that might make them vulnerable or who are in constant contact with people who may have other conditions. Some common sense is in order here. .
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Postby lightningBugout » Wed May 20, 2009 7:17 pm

Hear hear Chigger. Interesting sidenote - because nicotine withdrawal causes an inflammatory reaction, smokers may diminish their own cytokine response providing some protection against the cytokine storm risk associated with H1N1. Though I'd guess the respiratory infections and irritation cancel that out.

Just wanted to update --

he NYC toddler did not have H1N1

the VP in NYC had gout and was obese

the young man in UT (22) had underlying medical conditions

the husband of the pregnant woman in TX says the state's medical examiner is incorrect - that his wife had no other underlying condition

latest flu news says adults over 52 may have resistance to H1N1

carry on...

ps. sorry these aren't linked, my wireless is fucked up
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Postby Col. Quisp » Thu May 21, 2009 2:32 am

Whew...I just made it (I am 52). Also, a smoker. Yay for me!

though I feel a sore throat coming on.....
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Postby chiggerbit » Wed May 27, 2009 12:26 pm

This site has the most comprehensive collection of swine flu information that I've found anywhere:

http://www.thetreeofliberty.com/vb/foru ... y.php?f=29
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Postby Col. Quisp » Wed May 27, 2009 5:33 pm

I haven't been to the doctor to verify but I believe I now have the swine flu. Can't stop coughing, feel really tired, dizzy, having chest rales, headaches, body aches, a bit of nausea but it's brought on by the coughing fits. afraid to go to sleep because of the breathing difficulty. yesterday I had an out of body experience just before i woke up. I was still in bed, but was walking around in my bathroom, thinking, "ooh how filthy!" then i woke u.

Taking over the counter flu med seems to help with the coughing fits. I'm gonna stay away from doctors as long as possible, or until I start turning blue!
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Postby chiggerbit » Wed May 27, 2009 8:21 pm

Taking over the counter flu med seems to help with the coughing fits. I'm gonna stay away from doctors as long as possible, or until I start turning blue!


Be careful to not wait too long, Quispy.
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