Coronavirus Crisis: Main Thread

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Re: Manufactured 'Contagion' - Coronavirus Edition

Postby identity » Wed Mar 25, 2020 4:57 am

Once again, Vitamin D, folks! Maybe those people in their 30s, 40s, 50s apparently dying from COVID-19 have nutritional deficiencies that strongly increase their chances of succumbing? Just because that local dentist in his 60s here who died this week made a lot of money and had no obvious health problems does not mean he could not have been vit. D deficient. We don't get a lot of sun here in the winter, and it would not be surprising to find that a lot of people are D-deficient (and in my experience, people in allopathic medicine, dentistry, etc. are typically not big on supplementation).

Joe H. mentioned taking 1,000 IU a day, which I thought vastly too little, but then realized that he is in a sunny place and probably gets a lot more sunshine than I do (body exposed to sunlight at noon for 15 min. = +-10,000 IU). I live in a place that is overcast most of the year, and am a creature of the night. I'm taking around 10,000 IU daily (in liquid form). Glad now I stocked up when it was on sale!

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data
https://www.bmj.com/content/356/bmj.i6583
Conclusions and policy implications
Our study reports a major new indication for vitamin D supplementation: the prevention of acute respiratory tract infection. We also show that people who are very deficient in vitamin D and those receiving daily or weekly supplementation without additional bolus doses experienced particular benefit. Our results add to the body of evidence supporting the introduction of public health measures such as food fortification to improve vitamin D status, particularly in settings where profound vitamin D deficiency is common.

What is already known on this topic

Randomised controlled trials of vitamin D supplementation for the prevention of acute respiratory tract infection have yielded conflicting results
Individual participant data (IPD) meta-analysis has the potential to identify factors that may explain this heterogeneity, but this has not previously been performed
What this study adds

Meta-analysis of IPD from 10 933 participants in 25 randomised controlled trials showed an overall protective effect of vitamin D supplementation against acute respiratory tract infection (number needed to treat (NNT)=33)
Benefit was greater in those receiving daily or weekly vitamin D without additional bolus doses (NNT=20), and the protective effects against acute respiratory tract infection in this group were strongest in those with profound vitamin D deficiency at baseline (NNT=4)
These findings support the introduction of public health measures such as food fortification to improve vitamin D status, particularly in settings where profound vitamin D deficiency is common
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Re: Manufactured 'Contagion' - Coronavirus Edition

Postby 8bitagent » Wed Mar 25, 2020 6:03 am

Notice how language has changed, behavior has changed, and we're told the future has changed. This is a grand experiment regardless of what's going on. Endless anger from the left because Trump hadn't declared a total martial law shutdown and suspension of rights or sealed the border/banned foreign flights fast enough. Trump cult/ Right wingers who deny climate change exists, let alone is our greatest threat, finding this whole thing to be a "total hoax" with no nuance. Bernie is bad right, but suddenly both the Dems and Repubs who hate Bernie are sure wanting Bernie like policies? We're told on the news every minute of every day DONT LEAVE YOUR HOUSE or you could literally die and or put other people at risk. As if its an airborne agent out of M Night Shymalan's The Happening. You got a package? Leave it outside for a few days, then put on gloves and disinfect your Amazon slave warehouse warez. Trying to even have a conversation with fellow "liberals" about whats going on feels like arguing with Republicans during the Iraq war lead-up. and again the Trump/right wing we're told thinks its all a hoax.

Whatever is happening is not a hoax...obviously people are fighting for their lives. But what is it? Were told it was bats, like out of Soderbergh's 2011 Contagion film. Yet were bats being sold at the Chinese wet markets? Why does there seem like so many different mutations and strains but were told there isnt? Loss of smell and taste, loss of senses? Its eerily out of the recent pandemic film "Perfect Sense". The cfr/fatality rate seems insanely high in some areas yet "contained" and non existent in other alleged hot spots. Yet the entire planet is on lockdown. Hell what's going on reminds me of Bird Box from Netflix. Wouldnt be surprised if the stock collapse/great depression 2 and civil unrest isnt part of the plan? Were told how a lot of prisoners are being released yet gun stores are being kept open as "essential" shops(Im very much for prison reform, but just the optics of these two things happening at once is interesting)

Apparently noone in America took COVID-19 seriously and nothing got shutdown until Tom Hanks got infected, as well as NBA players on the same day. Now allegedly Harvey Weinstein has it. Maybe we'll find out posthumously Kobe Bryant had it too. Nothing makes sense.
We're told MILLIONS could die, that most of the citizens of America and the UK could get infected within weeks. Already mainstream speculation about the Great Depression 2.0(2009 recession? Ha!), mandatory vaccines, smart phone tracking of peoples movements, non vaccinated people not being able to travel next year, drones and robots enforcing mandatory lockdowns, military vehicles and hazmat masked military patrolling empty-yet once-sprawling major cities. Reality has become a feverish Alex Jones rant come to life mixed with a dystopic cyberpunk book or movie apparently.
And just when you think its gotten cray-cray crazy, CNN and NBC notifies you of even more "holy shit am i living in a feverish simulator" updates every few seconds that seems even more absurd. And those updates are minutes behind the Reddit Coronavirus news dumps which seem like they're all Onion articles but coming from seemingly reputable sources.

You're a terrorist if you even STEP FOOT outside your house or go for a walk at the park...why even super mega terror group ISIS has allegedly urged its adherents so social distance!

Again America "didnt take this seriously" and shut it down til Tom Hanks got infected. Tom Hanks, who starred in the Dan Brown conspiracy movie from 2016 where a biologic virus weapon in Italy by a shadowy group threatens to wipe out half the population.
"Do you know who I am? I am the arm, and I sound like this..."-man from another place, twin peaks fire walk with me
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Re: Manufactured 'Contagion' - Coronavirus Edition

Postby Belligerent Savant » Wed Mar 25, 2020 12:52 pm

.


Lots of charts in this missive. I don't see anything in the content that would justify Medium's removal of this piece.

https://straightlinelogic.com/2020/03/2 ... aron-ginn/



COVID-19 – Evidence Over Hysteria, by Aaron Ginn
Posted on March 22, 2020


Update [from Zero Hedge]:

Update (3/22/2020): After falling under much scrutiny, Medium has deleted Ginn’s post. Of note, Ginn is a former 2012 digital campaign staffer with no background in medicine or infectious disease.

We are leaving it up for anyone who wants to read, while also including a thread from a biologist who debunked it. Click on the tweet below to read.

Straightlinelogic will also leave this up for its readers, as well as access to the purported debunking from Carl T. Bergstrom below. Take it with a grain of salt; the original articles makes salient points, many of which are not addressed by Bergstrom at all. He’s also heavy into sarcasm and ad hominem attacks.

Error
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This post is under investigation or was found in violation of the Medium Rules.
There are thousands of stories to read on Medium. Visit our homepage
to find one that’s right for you.


COVID-19 – Evidence Over Hysteria

by Aaron Ginn

After watching the outbreak of COVID-19 for the past two months, I’ve followed the pace of the infection, its severity, and how our world is tackling the virus. While we should be concerned and diligent, the situation has dramatically elevated to a mob-like fear spreading faster than COVID-19 itself.

When 13% of Americans believe they are currently infected with COVID-19 (mathematically impossible), full-on panic is blocking our ability to think clearly and determine how to deploy our resources to stop this virus. Over three-fourths of Americans are scared of what we are doing to our society through law and hysteria, not of infection or spreading COVID-19 to those most vulnerable.

The following article is a systematic overview of COVID-19 driven by data from medical professionals and academic articles that will help you understand what is going on (sources include CDC, WHO, NIH, NHS, University of Oxford, Stanford, Harvard, NEJM, JAMA, and several others). I’m quite experienced at understanding virality, how things grow, and data. In my vocation, I’m most known for popularizing the “growth hacking movement” in Silicon Valley that specializes in driving rapid and viral adoption of technology products. Data is data. Our focus here isn’t treatments but numbers. You don’t need a special degree to understand what the data says and doesn’t say. Numbers are universal.

I hope you walk away with a more informed perspective on how you can help and fight back against the hysteria that is driving our country into a dark place. You can help us focus our scarce resources on those who are most vulnerable, who need our help.

Note: The following graphs and numbers are as of mid-March 2020. Things are moving quickly, so I update this article twice a day. Most graphs are as of March 20th, 2020.

* * *

Total cases are the wrong metric

A critical question to ask yourself when you first look at a data set is, “What is our metric for success?”.
Let’s start at the top. How is it possible that more than 20% of Americans believe they will catch COVID-19? Here’s how. Vanity metrics — a single data point with no context. Wouldn’t this picture scare you?

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Look at all of those large red scary circles!

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These images come from the now infamous John Hopkins COVID-19 tracking map. What started as a data transparency effort has now molded into an unintentional tool for hysteria and panic.

An important question to ask yourself is what do these bubbles actually mean? Each bubble represents the total number of COVID-19 cases per country. The situation looks serious, yet we know that this virus is over four months old, so how many of these cases are active?

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Immediately, we now see that just under half of those terrifying red bubbles aren’t relevant or actionable. The total number of cases isn’t illustrative of what we should do now. This is a single vanity data point with no context; it isn’t information or knowledge. To know how to respond, we need more numbers to tell a story and to paint the full picture. As a metaphor, the daily revenue of a business doesn’t tell you a whole lot about profitability, capital structure, or overhead. The same goes for the total number of cases. The data isn’t actionable. We need to look at ratios and percentages to tell us what to do next — conversion rate, growth rate, and severity.

Time lapsing new cases gives us perspective

Breaking down each country by the date of the first infection helps us track the growth and impact of the virus. We can see how total cases are growing against a consistent time scale.

Here are new cases time lapsed by country and date of first 100 total cases.

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Here is a better picture of US confirmed case daily growth.

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The United States is tracking with other European nations at doubling every three days or so. As we measure and test more Americans, this will continue to grow. Our time-lapse growth is lower than China, but not as good as South Korea, Japan, Singapore, or Taiwan. All are considered models of how to beat COVID-19. The United States is performing average, not great, compared to the other modern countries by this metric.

Still, there is a massive blindspot with this type of graph. None of these charts are weighted on a per-capita basis. It treats every country as a single entity, as we will see this fails to tell us what is going on in several aspects.


On a per-capita basis, we shouldn’t be panicking

Every country has a different population size which skews aggregate and cumulative case comparisons. By controlling for population, you can properly weigh the number of cases in the context of the local population size. Viruses don’t acknowledge our human borders. The US population is 5.5X greater than Italy, 6X larger than South Korea, and 25% the size of China. Comparing the US total number of cases in absolute terms is rather silly.

Rank ordering based on the total number of cases shows that the US on a per-capita basis is significantly lower than the top six nations by case volume. On a 1 million citizen per-capita basis, the US moves to above mid-pack of all countries and rising, with similar case volume as Singapore (385 cases), Cyprus (75 cases), and United Kingdom(3,983 cases). This is data as of March 20th, 2020.

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But total cases even on a per-capita basis will always be a losing metric. The denominator (total population) is more or less fixed. We aren’t having babies at the pace of viral growth. Per-capita won’t explain how fast the virus is moving and if it is truly “exponential”.

COVID-19 is spreading, but probably not accelerating

Growth rates are tricky to track over time. Smaller numbers are easy to move than larger numbers. As an example, GDP growth of 3% for the US means billions of dollars while 3% for Bermuda means millions. Generally, growth rates decline over time, but the nominal increase may still be significant. This holds true of daily confirmed case increases. Daily growth rates declined over time across all countries regardless of particular policy solutions, such as shutting the borders or social distancing.

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Weighing daily growth of confirmed cases by a relative daily growth factor cleans up the picture, more than 1 is increasing and below 1 is declining. For all of March, the world has hovered around 1.1. This translates to an average daily growth rate of 10%, with ups and downs on a daily basis. This isn’t great, but it is good news as COVID-19 most likely isn’t increasing in virality. The growth rate of the growth rate is approximately 10%; however, the data is quite noisy. With inconsistent country-to-country reporting and what qualifies as a confirmed case, the more likely explanation is that we are increasing our measurement, but the virus hasn’t increased in viral capability. Recommended containment and prevention strategies are still quite effective at stopping the spread.

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Cases globally are increasing (it is a virus after all!), but beware of believing metrics designed to intentionally scare like “cases doubling”. These are typically small numbers over small numbers and sliced on a per-country basis. Globally, COVID-19’s growth rate is rather steady. Remember, viruses ignore our national boundaries.

Viruses though don’t grow infinitely forever and forever. As with most things in nature, viruses follow a common pattern — a bell curve.

Watch the Bell Curve

As COVID-19 spreads and declines (which it will decline despite what the media tells you), every country will follow a similar pattern. The following is a more detailed graph of S. Korea’s successful defeat of COVID-19 compared also to China with thousands of more cases and deaths. It is a bell curve:

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Here is a more detailed graph of S. Korea graphed against the total number of cases.

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Here is a graph from Italy showing a bell curve in symptom onset and number of cases, which may point to the beginning of the end for Italy —

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JAMA — https://jamanetwork.com/journals/jama/p ... irus-alert

Bell curves is the dominant trait of outbreaks. A virus doesn’t grow linearly forever. It accelerates, plateaus, and then declines. Whether it is environmental or our own efforts, viruses accelerate and quickly decline. This fact of nature is represented in Farr’s law. CDC’s of “bend the curve” or “flatten the curve” reflects this natural reality.

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It is important to note that in both scenarios, the total number of COVID-19 cases will be similar. “Flattening the curve”’s focus is a shock to the healthcare system which can increase fatalities due to capacity constraints. In the long-term, it isn’t infection prevention. Unfortunately, “flattening the curve” doesn’t include other downsides and costs of execution.

Both the CDC and WHO are optimizing virality and healthcare utilization, while ignoring the economic shock to our system. Both organizations assume you are going to get infected, eventually, and it won’t be that bad.

A low probability of catching COVID-19

The World Health Organization (“WHO”) released a study on how China responded to COVID-19. Currently, this study is one of the most exhaustive pieces published on how the virus spreads.

The results of their research show that COVID-19 doesn’t spread as easily as we first thought or the media had us believe (remember people abandoned their dogs out of fear of getting infected). According to their report if you come in contact with someone who tests positive for COVID-19 you have a 1–5% chance of catching it as well. The variability is large because the infection is based on the type of contact and how long.

The majority of viral infections come from prolonged exposures in confined spaces with other infected individuals. Person-to-person and surface contact is by far the most common cause. From the WHO report, “When a cluster of several infected people occurred in China, it was most often (78–85%) caused by an infection within the family by droplets and other carriers of infection in close contact with an infected person.

From the CDC’s study on transmission in China and Princess Cruise outbreak –

A growing body of evidence indicates that COVID-19 transmission is facilitated in confined settings; for example, a large cluster (634 confirmed cases) of COVID-19 secondary infections occurred aboard a cruise ship in Japan, representing about one fifth of the persons aboard who were tested for the virus. This finding indicates the high transmissibility of COVID-19 in enclosed spaces

Dr. Paul Auwaerter, the Clinical Director for the Division of Infectious Diseases at Johns Hopkins University School of Medicine echoes this finding,

“If you have a COVID-19 patient in your household, your risk of developing the infection is about 10%….If you were casually exposed to the virus in the workplace (e.g., you were not locked up in conference room for six hours with someone who was infected [like a hospital]), your chance of infection is about 0.5%

According to Dr. Auwaerter, these transmission rates are very similar to the seasonal flu.

Air-based transmission or untraceable community spread is very unlikely. According to WHO’s COVID-19 lead Maria Van Kerkhove, true community based spreading is very rare. The data from China shows that community-based spread was only a very small handful of cases. “This virus is not circulating in the community, even in the highest incidence areas across China,” Van Kerkhove said.

“Transmission by fine aerosols in the air over long distances is not one of the main causes of spread. Most of the 2,055 infected hospital workers were either infected at home or in the early phase of the outbreak in Wuhan when hospital safeguards were not raised yet,” she said.

True community spread involves transmission where people get infected in public spaces and there is no way to trace back the source of infection. WHO believes that is not what the Chinese data shows. If community spread was super common, it wouldn’t be possible to reduce the new cases through “social distancing”.

“We have never seen before a respiratory pathogen that’s capable of community transmission but at the same time which can also be contained with the right measures. If this was an influenza epidemic, we would have expected to see widespread community transmission across the globe by now and efforts to slow it down or contain it would not be feasible,” said Tedros Adhanom, Director-General of WHO.

An author of a working paper from the Department of Ecology and Evolutionary Biology at Princeton University said, “The current scientific consensus is that most transmission via respiratory secretions happens in the form of large respiratory droplets … rather than small aerosols. Droplets, fortunately, are heavy enough that they don’t travel very far and instead fall from the air after traveling only a few feet.”

The media was put into a frenzy when the above authors released their study on COVID-19’s ability to survive in the air. The study did find the virus could survive in the air for a couple of hours; however, this study was designed as academic exercise rather than a real-world test. This study put COVID-19 into a spray bottle to “mist” it into the air. I don’t know anyone who coughs in mist form and it is unclear if the viral load was large enough to infect another individual As one doctor, who wants to remain anonymous, told me, “Corona doesn’t have wings”.

To summarize, China, Singapore, and South Korea’s containment efforts worked because community-based and airborne transmission aren’t common. The most common form of transmission is person-to-person or surface-based.


Common transmission surfaces

COVID-19’s ability to live for a long period of time is limited on most surfaces and it is quite easy to kill with typical household cleaners, just like the normal flu.

COVID-19 be detected on copper after 4 hours and 24 hours on cardboard.
COVID-19 survived best on plastic and stainless steel, remaining viable for up to 72 hours
COVID-19 is very vulnerable to UV light and heat.

Presence doesn’t mean infectious. The viral concentration falls significantly over time. The virus showed a half-life of about 0.8 hours on copper, 3.46 hours on cardboard, 5.6 hours on steel and 6.8 hours on plastic.

According to Dylan Morris, one of the authors, “We do not know how much virus is actually needed to infect a human being with high probability, nor how easily the virus is transferred from the cardboard to one’s hand when touching a package”

According to Dr. Auwaerter, “It’s thought that this virus can survive on surfaces such as hands, hard surfaces, and fabrics. Preliminary data indicates up to 72 hours on hard surfaces like steel and plastic, and up to 12 hours on fabric.”

....
[snip]

1% of cases will be severe

Looking at the whole funnel from top to bottom, ~1% of everyone who is tested for COVID-19 with the US will have a severe case [author’s emphasis] that will require a hospital visit or long-term admission.

Globally, 80–85% of all cases are mild. These will not require a hospital visit and home-based treatment/ no treatment is effective.

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As of mid-March, the US has a significantly lower case severity rate than other countries. Our current severe caseload is similar to South Korea. This data has been spotty in the past; however, lower severity is reflected in the US COVID-19 fatality rates (addressed later).

Early reports from CDC, suggest that 12% of COVID-19 cases need some form of hospitalization, which is lower than the projected severity rate of 20%, with 80% being mild cases.

For context, this year’s flu season has led to at least 17 million medical visits and 370,000 hospitalizations (0.1%) out of 30–50 million infections. Recalling that only comparing aggregate total cases isn’t helpful, breaking down active cases on a per-capita basis paints a different picture on severity. This is data as of March 20th, 2020.

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Declining fatality rate

As the US continues to expand testing, the case fatality rate will decline over the next few weeks. There is little doubt that serious and fatal cases of COVID-19 are being properly recorded. What is unclear is the total size of mild cases. WHO originally estimated a case fatality rate of 4% at the beginning of the outbreak but revised estimates downward 2.3% — 3% for all age groups. CDC estimates 0.5% — 3%, however stresses that closer to 1% is more probable. Dr. Paul Auwaerter estimated 0.5% — 2%, leaning towards the lower end. A paper released on March 19th analyzed a wider data set from China and lowered the fatality rate to 1.4%. This won’t be clear for the US until we see the broader population that is positive but with mild cases. With little doubt, the fatality rate and severity rate will decline as more people are tested and more mild cases are counted.

Higher fatality rates in China, Iran, and Italy are more likely associated with a sudden shock to the healthcare system unable to address demands and doesn’t accurately reflect viral fatality rates. As COVID-19 spread throughout China, the fatality rate drastically fell outside of Hubei. This was attributed to the outbreak slowing spreading to several provinces with low infection rates.

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John P.A. Ioannidis is professor of medicine, of epidemiology and population health, of biomedical data science, and of statistics at Stanford University and co-director of Stanford’s Meta-Research Innovation Center recently wrote about fatality rates and how our current instrumentation is leading to faulty policy solutions:

“The one situation where an entire, closed population was tested was the Diamond Princess cruise ship and its quarantine passengers. The case fatality rate there was 1.0%, but this was a largely elderly population, in which the death rate from Covid-19 is much higher.

Projecting the Diamond Princess mortality rate onto the age structure of the U.S. population, the death rate among people infected with Covid-19 would be 0.125%. But since this estimate is based on extremely thin data — there were just seven deaths among the 700 infected passengers and crew — the real death rate could stretch from five times lower (0.025%) to five times higher (0.625%). It is also possible that some of the passengers who were infected might die later, and that tourists may have different frequencies of chronic diseases — a risk factor for worse outcomes with SARS-CoV-2 infection — than the general population. Adding these extra sources of uncertainty…”


“Reasonable estimates for the case fatality ratio in the general U.S. population vary from 0.05% to 1%.”


Looking at the US fatality, the fatality rate is drastically declining as the number of cases increases, halving every four or five days. The fatality rate will eventually level off and plateau as the US case-mix becomes apparent.

4.06% March 8 (22 deaths of 541 cases)
3.69% March 9 (26 of 704)
3.01% March 10 (30 of 994)
2.95% March 11 (38 of 1,295)
2.52% March 12 (42 of 1,695)
2.27% March 13 (49 of 2,247)
1.93% March 14 (57 of 2,954)
1.84% March 15 (68 of 3,680)
1.90% March 16 (86 of 4,503)
1.76% March 17 (109 of 6,196)
1.66% March 18 (150 of 9,003)
1.51% March 19th (208 of 13,789)
1.32% March 20th (256 of 19,383)

[snip]

...

Another analysis by Nature, comparing the fatality rate (since revised down) and infectious rate of COVID-19 to other illnesses. COVID-19 is now within range of its other sisters of less potent coronaviruses.

As the global health community continues to gather and report data, the claim that “COVID-19 isn’t just like the flu” (though still severe) is looking less credible as fatality rates continue to decline and measuring of mild cases increases.

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It is important to consider case-mix when looking at fatality rates. The fatality rate is significantly higher for patients with an underlying condition.

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The fatality rates by underling condition mimics the rise in the average fatality rate with those with underlying conditions who get the seasonal flu.


Pneumonia and influenza: 1.53% — 1.93%
Chronic lower respiratory disease: 1.48% — 1.93%
All respiratory causes: 3.04% — 4.14%
Heart disease: 3.21% — 4.4%
Cancer: 0.68% — 1.05%
Diabetes: 0.26% — 0.39%
For all underlying conditions: 10.17% — 13.67%.

Comparing case-mix across countries with a wide range of fatality (China and Italy) and those with low fatality rates (S. Korea) reveals a stark difference in age; therefore, underlying conditions also vary significantly across countries. These two factors contribute the most to a country’s fatality rate.

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Divided by most at risk and low risk, Italy had significantly more cases of high at-risk patients than Germany or Korea:

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Based on an initial CDC study of 2,449 COVID-19 cases (almost half of current US cases have missing demographic data), the United States case-mix looks more like S. Korea and Germany rather than China or Italy. Approximately 69% of COVID-19 cases are in the lower at-risk population of under 65, while 31% are older than 65 higher risk population.

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This suggests the US will experience a declining fatality rate; however, the US has over 100 million adults with underlying and chronic illnesses that will negatively impact our fatality rate.

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An older population skew within the infected population explains most of the disparity in fatality rates between high and low countries. According to a study of the fatalities of COVID-19 cases in Italy, 99% of all deaths had an underlying pathology. Only 0.8% had no underlying condition.


[snip]

So what should we do?

The first rule of medicine is to do no harm.

Local governments and politicians are inflicting massive harm and disruption with little evidence to support their draconian edicts. Every local government is in a mimetic race to one-up each other in authoritarian city ordinances to show us who has more “abundance of caution”. Politicians are competing, not on more evidence or more COVID-19 cures but more caution. As unemployment rises and families feel unbearably burdened already, they feel pressure to “fix” the situation they created with even more radical and “creative” policy solutions. This only creates more problems and an even larger snowball effect. The first place to start is to stop killing the patient and focus on what works.

Start with basic hygiene

The most effective means to reduce spread is basic hygiene. Most American’s don’t wash their hands enough and aren’t aware of how to actually wash your hands. Masks aren’t particularly effective if you touch your eyes with infected hands. Ask businesses and public places to freely distribute disinfectant wipes and hand sanitizer to the customers and patrons. If you get sick or feel sick, stay home. These are basic rules for preventing illness that doesn’t require trillions of dollars.

More data

The best examples of defeating COVID-19 requires lots of data. We are very behind in measuring our population and the impact of the virus but this has turned a corner the last few days. The swift change in direction should be applauded. Private companies are quickly developing and deploying tests, much faster than CDC could ever imagine. The inclusion of private businesses in developing solutions is creative and admirable. Data will calm nerves and allow us to utilize more evidence in our strategy. Once we have proper measurement implemented (the ability to test hundreds every day in a given metro), let’s add even more data into that funnel — reopen public life.

Open schools

Closing schools is counterproductive. The economic cost for closing schools in the U.S. for four weeks could cost between $10 and $47 billion dollars (0.1–0.3% of GDP) and lead to a reduction of 6% to 19% in key health care personnel.

CDC’s guidance on closing schools specifically for COVID-19 –

Available modeling data indicate that early, short to medium closures do not impact the epi curve of COVID-19 or available health care measures (e.g., hospitalizations). There may be some impact of much longer closures (8 weeks, 20 weeks) further into community spread, but that modeling also shows that other mitigation efforts (e.g., handwashing, home isolation) have more impact on both spread of disease and health care measures. In other countries, those places who closed school (e.g., Hong Kong) have not had more success in reducing spread than those that did not (e.g., Singapore).

Based on transmission evidence children are more likely to catch COVID-19 in the home than at school. As well, they are more likely to expose older vulnerable adults as multi-generational homes are more common. As well, the school provides a single point of testing a large population for a possible infection in the home to prevent community spread.

Open up public spaces

With such little evidence of prolific community spread and our guiding healthcare institutions reporting the same results, shuttering the local economy is a distraction and arbitrary with limited accretive gain outside of greatly annoying millions and bankrupting hundreds of businesses. The data is overwhelming at this point that community-based spread and airborne transmission is not a threat. We don’t have significant examples of spreading through restaurants or gyms. When you consider the environment COVID-19 prefers, isolating every family in their home is a perfect situation for infection and transmission among other family members. Evidence from South Korea and Singapore shows that it is completely possible and preferred to continue on with life while making accommodations that are data-driven, such as social distancing and regular temperature checks.

Support business and productivity

The data shows that the overwhelming majority of the working population will not be personally impacted, both individually or their children. This is an unnecessary burden that is distracting resources and energy away from those who need it the most. By preventing Americans from being productive and specializing at what they do best (their vocation), we are pulling resources towards unproductive tasks and damaging the economy. We will need money for this fight.

At this rate, we will spend more money on “shelter-in-place” than if we completely rebuilt our acute care and emergency capacity.

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Source: https://www.macrobond.com/posts/blog-ce ... sh-crisis/

Americans won’t have the freedom to go help those who get sick, volunteer their time at a hospital, or give generously to a charity. Instead, big government came barrelling in like a bull in a china shop claiming they could solve COVID-19. The same government that continued to not test incoming passengers from Europe and who couldn’t manufacture enough test kits with two months’ notice.

Let Americans be free to be a part of the solution, calling us to a higher civic duty to help those most in need and protect the vulnerable. Not sitting in isolation like losers.

People fear what the government will do, not an infection

Rampant hoarding and a volatile stock market aren’t being driven by COVID-19. An overwhelming majority of American’s don’t believe they will be infected. Rather hoarding behavior strongly demonstrates an irrational hysteria, from purchasing infective household masks to buying toilet paper in the troves. This fear is being driven by government action, fearing what the government will do next. In South Korea, most citizens didn’t fear infection but the government and public shaming. By presenting a consistent and clear plan that is targeted and specific to those who need the most help will reduce the volatility and hysteria. A sign the logic behind these government actions aren’t widely accepted, nor believed as rational by the American people is the existence itself of the volatility and hysteria. Over three-fourths of Americans are scared not of COVID-19 but what it is doing to our society.

In CDC’s worst-case scenario, CDC expects more than 150–200 million infections within the US. This estimate is hundreds of times bigger than China’s infection rate (30% of our population compared to 0.006% in China). Does that really sound plausible to you? China has a sub-par healthcare system, attempted to suppress the news about COVID-19 early on, a lack of transparency, an authoritarian government, and millions of Chinese traveling for the Lunar Festival at the height of the outbreak. In the US, we have a significant lead time, several therapies proving successful, transparency, a top tier healthcare system, a democratic government, and media providing ample accountability.

Infection isn’t our primary risk at this point.

Expand medical capacity

COVID-19 is a significant medical threat that needs to be tackled, both finding a cure and limiting spread; however, some would argue that a country’s authoritarian response to COVID-19 helped stop the spread. Probably not. In South Korea and Taiwan, I can go to the gym and eat at a restaurant which is more than I can say about San Francisco and New York, despite a significantly lower caseload on a per-capita basis.

None of the countries the global health authorities admire for their approach issued “shelter-in-place” orders, rather they used data, measurement,and promoted common sense self-hygiene.

Does stopping air travel have a greater impact than closing all restaurants? Does closing schools reduce the infection rate by 10%? Not one policymaker has offered evidence of any of these approaches. Typically, the argument given is “out of an abundance of caution”. I didn’t know there was such a law. Let’s be frank, these acts are emotionally driven by fear, not evidence-based thinking in the process of destroying people’s lives overnight. While all of these decisions are made by elites isolated in their castles of power and ego, the shock is utterly devastating Main Street.

A friend who runs a guy will run out of cash in a few weeks. A friend who is a pastor let go of half of his staff as donations fell by 60%. A waitress at my favorite breakfast place told me her family will have no income in a few days as they force the closure of restaurants. While political elites twiddle their thumbs with models and projections based on faulty assumptions, people’s lives are being destroyed with Marxian vigor. The best compromise elites can come up with is $2,000.

Does it make more sense for us to pay a tax to expand medical capacity quickly or pay the cost to our whole nation of a recession? Take the example of closing schools which will easily cost our economy $50 billion. For that single unanimous totalitarian act, we could have built 50 hospitals with 500+ beds per hospital.

Eliminate arcane certificate of need and expand acute medical capacity to support possible higher healthcare utilization this season.

---

These days are precarious as Governors float the idea of martial law for not following “social distancing”, as well as they liked while they violate those same rules on national TV. Remember this tone is for a virus that has impacted 0.004% of our population. Imagine if this was a truly existential threat to our Republic.

The COVID-19 hysteria is pushing aside our protections as individual citizens and permanently harming our free, tolerant, open civil society. Data is data. Facts are facts. We should be focused on resolving COVID-19 with continued testing, measuring, and be vigilant about protecting those with underlying conditions and the elderly from exposure. We are blessed in one way, there is an election in November. Never forget what happened and vote.

You may ask yourself. Who is this guy? Who is this author? I’m a nobody. That is also the point. The average American feels utterly powerless right now. I’m an individual American who sees his community and loved ones being decimated without given a choice, without empathy, and while the media cheers on with high ratings.

When this is all over, look for massive confirmation bias and pyrrhic celebration by elites. There will be vain cheering in the halls of power as Main Street sits in pieces. Expect no apology, that would be political suicide. Rather, expect to be given a Jedi mind trick of “I’m the government and I helped.”

The health of the State will be even stronger with more Americans dependent on welfare, another trillion stimulus filled with pork for powerful friends, and a bailout for companies that charged us $200 change fees for nearly a decade. Washington DC will be fine. New York will still have all of the money in the world. Our communities will be left with nothing but a shadow of the longest bull market in the history of our country.
...

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Re: Manufactured 'Contagion' - Coronavirus Edition

Postby Wombaticus Rex » Wed Mar 25, 2020 3:53 pm

Belligerent Savant » Wed Mar 25, 2020 11:52 am wrote:.


Lots of charts in this missive. I don't see anything in the content that would justify Medium's removal of this piece.


You mean like the part where Ginn states that "1% of all cases will be severe" and follows that up with a graph stating that "2.3% of all cases died," while showing a pyramid that displays "14% severe cases" and "5% critical cases" -- like that sort of thing?

Or this doozy of a switcheroo, only a few sentences apart:

Cases globally are increasing (it is a virus after all!), but beware of believing metrics designed to intentionally scare like “cases doubling”. These are typically small numbers over small numbers and sliced on a per-country basis. Globally, COVID-19’s growth rate is rather steady. Remember, viruses ignore our national boundaries.


Then, mere seconds later -- he's arguing a bell curve using data sliced on a per-country basis, despite the fact that viruses ignore our national boundaries.

As COVID-19 spreads and declines (which it will decline despite what the media tells you), every country will follow a similar pattern. The following is a more detailed graph of S. Korea’s successful defeat of COVID-19 compared also to China with thousands of more cases and deaths. It is a bell curve:

...

Here is a graph from Italy showing a bell curve in symptom onset and number of cases, which may point to the beginning of the end for Italy —


As I've said here a lot, just because it's easy to tear down the speculative models of dudes like this doesn't mean it's easy to build a correct model. Our understanding of nCoV is still in a "pre-paradigm state" and there is a shit-ton of noise in the data, confounded by political considerations, hugely insufficient testing, and uncertainty about what the major contributing factors are. (Outside of old age and pre-existing health conditions, of course -- those are a safe bet!)
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Re: Manufactured 'Contagion' - Coronavirus Edition

Postby Cordelia » Wed Mar 25, 2020 4:13 pm

Some good news from 2 U.S. cities on each coast:

Coronavirus: Crime rates in NYC and LA drop as more people stay inside...

https://www.businessinsider.com/coronav ... rts-2020-3


...and don’t want to get close enough to kill each other (for now anyway):

Serious felonies, murders, and arrests all dropped in NYC during the week of March 16 through March 22 compared to 2019, the Journal reported. LA also reported a 5.8% drop in crime this year compared to the previous year, according to the LA Times.


But if you live in Chicago? Never mind.

However, killings in Chicago increased by 43% compared to the previous year, according to the Chicago Sun-Times.
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Re: Manufactured 'Contagion' - Coronavirus Edition

Postby Belligerent Savant » Wed Mar 25, 2020 4:38 pm

Wombaticus Rex » Wed Mar 25, 2020 2:53 pm wrote:
Belligerent Savant » Wed Mar 25, 2020 11:52 am wrote:.


Lots of charts in this missive. I don't see anything in the content that would justify Medium's removal of this piece.


You mean like the part where Ginn states that "1% of all cases will be severe" and follows that up with a graph stating that "2.3% of all cases died," while showing a pyramid that displays "14% severe cases" and "5% critical cases" -- like that sort of thing?

Or this doozy of a switcheroo, only a few sentences apart:

Cases globally are increasing (it is a virus after all!), but beware of believing metrics designed to intentionally scare like “cases doubling”. These are typically small numbers over small numbers and sliced on a per-country basis. Globally, COVID-19’s growth rate is rather steady. Remember, viruses ignore our national boundaries.


Then, mere seconds later -- he's arguing a bell curve using data sliced on a per-country basis, despite the fact that viruses ignore our national boundaries.

As COVID-19 spreads and declines (which it will decline despite what the media tells you), every country will follow a similar pattern. The following is a more detailed graph of S. Korea’s successful defeat of COVID-19 compared also to China with thousands of more cases and deaths. It is a bell curve:

...

Here is a graph from Italy showing a bell curve in symptom onset and number of cases, which may point to the beginning of the end for Italy —


As I've said here a lot, just because it's easy to tear down the speculative models of dudes like this doesn't mean it's easy to build a correct model. Our understanding of nCoV is still in a "pre-paradigm state" and there is a shit-ton of noise in the data, confounded by political considerations, hugely insufficient testing, and uncertainty about what the major contributing factors are. (Outside of old age and pre-existing health conditions, of course -- those are a safe bet!)



Yes, there are some flawed extrapolations/points raised in the piece; everything related to this topic is subject to change (and I believe the author indicated as much as a general disclaimer), minimally for the next few weeks -- we haven't yet peaked her in the U.S., though we may not be as far away from a peak as initially projected.

There's also some useful information in there as well.

Did he purport to be an authority, though? Is he publishing this content on an established peer-reviewed forum? Are there far more egregious instances of mis/disinfo out there, far more accessible to the mainstream, promoted and still available to the masses?

Scrutiny is needed, surely. I'm not debating that. And it may be that in this instance, due to the amount of attention this piece received within a short timeframe, an 'executive decision' was made to remove it outright, rather than counter with corrections/flagging for inconsistencies. But Medium's decision to remove it was an excessive step.
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Re: Manufactured 'Contagion' - Coronavirus Edition

Postby Wombaticus Rex » Wed Mar 25, 2020 4:56 pm

Belligerent Savant » Wed Mar 25, 2020 3:38 pm wrote:Scrutiny is needed, surely. I'm not debating that. And it may be that in this instance, due to the amount of attention this piece received within a short timeframe, an 'executive decision' was made to remove it outright, rather than counter with corrections/flagging for inconsistencies. But Medium's decision to remove it was an excessive step.


Oh, I agree -- but if you think about it, that's also just a further indictment of Ginn's piece, where he takes CDC and WHO (and CHINESE!!!) numbers at face value and uses them as the basis for his argument.

Now, I also happen to agree with Ginn on several points: 1) small businesses cannot afford these closures because they have low margins, high overhead, and very little cash on hand, 2) the US economy absolutely cannot afford to be shut down without facing an even more massive recession than the one it was already facing due to massive asset bubbles, leveraged fracking, and a McJobs economy that has been steadily suppressing US consumer demand, the engine of the global economy, and 3) the CFR for this will continually trend lower as we get more, and better, data and more widespread testing.

As for Medium, the platform has been much quicker to censor since Trump got elected -- true for a wide swath of the Internet. As we've mentioned here before, the Event 201 drill was comically preoccupied with the need to stomp out "online disinformation," which is funny in light of WHO's claim of no human-to-human transmission, or CDC's advice against the public using masks. The SV tech community recently got to have their "We Are The World" moment in the sun, so expect a lot more of that.

...and as for the core argument? Fuck it, what difference does it make? The United States has yet to even start a serious lockdown, our medical system is already being overloaded in several cities, so what difference does it really make? Let it burn, right? Let it fucking burn. Let Aaron Ginn enjoy his crossfit classes in peace. Until it's too late.

The big winners will be Amazon and Wal Mart -- oh, and all the people who don't die. But you can't prove they would have died unless they actually do, right? Right?
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Re: Manufactured 'Contagion' - Coronavirus Edition

Postby norton ash » Wed Mar 25, 2020 5:05 pm

Again America "didnt take this seriously" and shut it down til Tom Hanks got infected. Tom Hanks, who starred in the Dan Brown conspiracy movie from 2016 where a biologic virus weapon in Italy by a shadowy group threatens to wipe out half the population.


This America of yours sounds interesting. Tom Hanks is a minor sidenote, but apparently he's a real hobbyhorse for you crackpot HMW types who know better than everyone.

Enough people in money and power took it seriously enough to dump their stock. And anyone with a working brain knew it was coming and took it very seriously way the fuck before Tom fucking Hanks.
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Re: Manufactured 'Contagion' - Coronavirus Edition

Postby Belligerent Savant » Wed Mar 25, 2020 5:40 pm

.

Wombaticus Rex » Wed Mar 25, 2020 3:56 pm wrote:Let Aaron Ginn enjoy his crossfit classes in peace. Until it's too late.


Wait - Ginn does crossfit? Is he Vegan as well? If so, he must be extinguished by fire. Blowtorch, preferably.

As far your other points. What else can be said, other than lamenting the perpetual machinations of Empire? Perhaps with more emphasis on sardonic irreverence. What else can us plebes do? I mean, besides carrying on despite it all. We shall persevere! Until we are no more.
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Re: Manufactured 'Contagion' - Coronavirus Edition

Postby MacCruiskeen » Wed Mar 25, 2020 5:59 pm

We are all going to have to get real.

We are still, just, at a stage when laughing at this madness might help, but only if we do it together and in public. And carefully, and kindly. Speak to your neighbours, carefully, tactfully, unfrightenedly, kindly. Ask them, with good humour but not flippantly, what they really think.

Respect their boundaries of course, and look them unfrightenedly in the eye.

Here in Germany workingclass people are by far the sanest and least frightened. Supermarket workers are completely unfrightened, and healthy, and laughing.

What does that tell us about this alleged deadly pandemic?
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Re: Manufactured 'Contagion' - Coronavirus Edition

Postby JackRiddler » Wed Mar 25, 2020 6:14 pm

Wombaticus Rex » Wed Mar 25, 2020 2:53 pm wrote:As I've said here a lot, just because it's easy to tear down the speculative models of dudes like this doesn't mean it's easy to build a correct model. Our understanding of nCoV is still in a "pre-paradigm state" and there is a shit-ton of noise in the data, confounded by political considerations, hugely insufficient testing, and uncertainty about what the major contributing factors are. (Outside of old age and pre-existing health conditions, of course -- those are a safe bet!)


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Re: Manufactured 'Contagion' - Coronavirus Edition

Postby MacCruiskeen » Wed Mar 25, 2020 6:24 pm

oh ffs. Wait forever. Stroke your chin and spectate and consume acres of data, and wait, and consider "judiciously , as you will" (sic, Karl Rove had your/our number), and wait. Trust "the [carefully selected, careerist] experts" in the corporate-state mass media that have been lying to us with impunity for years.

Like hell. Trust the working class instead. Trust the supermarket workers. They know. They are healthy, they are laughing, and they are beginning to get a wee bit annoyed. Uppity.

And christ knows: not for no reason.
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Re: Manufactured 'Contagion' - Coronavirus Edition

Postby liminalOyster » Wed Mar 25, 2020 8:04 pm

How the Pandemic Will End
The U.S. may end up with the worst COVID-19 outbreak in the industrialized world. This is how it’s going to play out.


Joan Wong
Story by Ed Yong
12:53 PM ET
HEALTH
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Editor’s Note: The Atlantic is making vital coverage of the coronavirus available to all readers. Find the collection here.
Three months ago, no one knew that SARS-CoV-2 existed. Now the virus has spread to almost every country, infecting at least 446,000 people whom we know about, and many more whom we do not. It has crashed economies and broken health-care systems, filled hospitals and emptied public spaces. It has separated people from their workplaces and their friends. It has disrupted modern society on a scale that most living people have never witnessed. Soon, most everyone in the United States will know someone who has been infected. Like World War II or the 9/11 attacks, this pandemic has already imprinted itself upon the nation’s psyche.

A global pandemic of this scale was inevitable. In recent years, hundreds of health experts have written books, white papers, and op-eds warning of the possibility. Bill Gates has been telling anyone who would listen, including the 18 million viewers of his TED Talk. In 2018, I wrote a story for The Atlantic arguing that America was not ready for the pandemic that would eventually come. In October, the Johns Hopkins Center for Health Security war-gamed what might happen if a new coronavirus swept the globe. And then one did. Hypotheticals became reality. “What if?” became “Now what?”

So, now what? In the late hours of last Wednesday, which now feels like the distant past, I was talking about the pandemic with a pregnant friend who was days away from her due date. We realized that her child might be one of the first of a new cohort who are born into a society profoundly altered by COVID-19. We decided to call them Generation C.

As we’ll see, Gen C’s lives will be shaped by the choices made in the coming weeks, and by the losses we suffer as a result. But first, a brief reckoning. On the Global Health Security Index, a report card that grades every country on its pandemic preparedness, the United States has a score of 83.5—the world’s highest. Rich, strong, developed, America is supposed to be the readiest of nations. That illusion has been shattered. Despite months of advance warning as the virus spread in other countries, when America was finally tested by COVID-19, it failed.

Anne Applebaum: The coronavirus called America’s bluff

“No matter what, a virus [like SARS-CoV-2] was going to test the resilience of even the most well-equipped health systems,” says Nahid Bhadelia, an infectious-diseases physician at the Boston University School of Medicine. More transmissible and fatal than seasonal influenza, the new coronavirus is also stealthier, spreading from one host to another for several days before triggering obvious symptoms. To contain such a pathogen, nations must develop a test and use it to identify infected people, isolate them, and trace those they’ve had contact with. That is what South Korea, Singapore, and Hong Kong did to tremendous effect. It is what the United States did not.

As my colleagues Alexis Madrigal and Robinson Meyer have reported, the Centers for Disease Control and Prevention developed and distributed a faulty test in February. Independent labs created alternatives, but were mired in bureaucracy from the FDA. In a crucial month when the American caseload shot into the tens of thousands, only hundreds of people were tested. That a biomedical powerhouse like the U.S. should so thoroughly fail to create a very simple diagnostic test was, quite literally, unimaginable. “I’m not aware of any simulations that I or others have run where we [considered] a failure of testing,” says Alexandra Phelan of Georgetown University, who works on legal and policy issues related to infectious diseases.

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The testing fiasco was the original sin of America’s pandemic failure, the single flaw that undermined every other countermeasure. If the country could have accurately tracked the spread of the virus, hospitals could have executed their pandemic plans, girding themselves by allocating treatment rooms, ordering extra supplies, tagging in personnel, or assigning specific facilities to deal with COVID-19 cases. None of that happened. Instead, a health-care system that already runs close to full capacity, and that was already challenged by a severe flu season, was suddenly faced with a virus that had been left to spread, untracked, through communities around the country. Overstretched hospitals became overwhelmed. Basic protective equipment, such as masks, gowns, and gloves, began to run out. Beds will soon follow, as will the ventilators that provide oxygen to patients whose lungs are besieged by the virus.

Read: The people ignoring social distancing

With little room to surge during a crisis, America’s health-care system operates on the assumption that unaffected states can help beleaguered ones in an emergency. That ethic works for localized disasters such as hurricanes or wildfires, but not for a pandemic that is now in all 50 states. Cooperation has given way to competition; some worried hospitals have bought out large quantities of supplies, in the way that panicked consumers have bought out toilet paper.

Partly, that’s because the White House is a ghost town of scientific expertise. A pandemic-preparedness office that was part of the National Security Council was dissolved in 2018. On January 28, Luciana Borio, who was part of that team, urged the government to “act now to prevent an American epidemic,” and specifically to work with the private sector to develop fast, easy diagnostic tests. But with the office shuttered, those warnings were published in The Wall Street Journal, rather than spoken into the president’s ear. Instead of springing into action, America sat idle.

Derek Thompson: America is acting like a failed state

Rudderless, blindsided, lethargic, and uncoordinated, America has mishandled the COVID-19 crisis to a substantially worse degree than what every health expert I’ve spoken with had feared. “Much worse,” said Ron Klain, who coordinated the U.S. response to the West African Ebola outbreak in 2014. “Beyond any expectations we had,” said Lauren Sauer, who works on disaster preparedness at Johns Hopkins Medicine. “As an American, I’m horrified,” said Seth Berkley, who heads Gavi, the Vaccine Alliance. “The U.S. may end up with the worst outbreak in the industrialized world.”

I. The Next Months
Having fallen behind, it will be difficult—but not impossible—for the United States to catch up. To an extent, the near-term future is set because COVID-19 is a slow and long illness. People who were infected several days ago will only start showing symptoms now, even if they isolated themselves in the meantime. Some of those people will enter intensive-care units in early April. As of last weekend, the nation had 17,000 confirmed cases, but the actual number was probably somewhere between 60,000 and 245,000. Numbers are now starting to rise exponentially: As of Wednesday morning, the official case count was 54,000, and the actual case count is unknown. Health-care workers are already seeing worrying signs: dwindling equipment, growing numbers of patients, and doctors and nurses who are themselves becoming infected.

Italy and Spain offer grim warnings about the future. Hospitals are out of room, supplies, and staff. Unable to treat or save everyone, doctors have been forced into the unthinkable: rationing care to patients who are most likely to survive, while letting others die. The U.S. has fewer hospital beds per capita than Italy. A study released by a team at Imperial College London concluded that if the pandemic is left unchecked, those beds will all be full by late April. By the end of June, for every available critical-care bed, there will be roughly 15 COVID-19 patients in need of one. By the end of the summer, the pandemic will have directly killed 2.2 million Americans, notwithstanding those who will indirectly die as hospitals are unable to care for the usual slew of heart attacks, strokes, and car accidents. This is the worst-case scenario. To avert it, four things need to happen—and quickly.

Read: All the president’s lies about the coronavirus

The first and most important is to rapidly produce masks, gloves, and other personal protective equipment. If health-care workers can’t stay healthy, the rest of the response will collapse. In some places, stockpiles are already so low that doctors are reusing masks between patients, calling for donations from the public, or sewing their own homemade alternatives. These shortages are happening because medical supplies are made-to-order and depend on byzantine international supply chains that are currently straining and snapping. Hubei province in China, the epicenter of the pandemic, was also a manufacturing center of medical masks.

In the U.S., the Strategic National Stockpile—a national larder of medical equipment—is already being deployed, especially to the hardest-hit states. The stockpile is not inexhaustible, but it can buy some time. Donald Trump could use that time to invoke the Defense Production Act, launching a wartime effort in which American manufacturers switch to making medical equipment. But after invoking the act last Wednesday, Trump has failed to actually use it, reportedly due to lobbying from the U.S. Chamber of Commerce and heads of major corporations.

Some manufacturers are already rising to the challenge, but their efforts are piecemeal and unevenly distributed. “One day, we’ll wake up to a story of doctors in City X who are operating with bandanas, and a closet in City Y with masks piled into it,” says Ali Khan, the dean of public health at the University of Nebraska Medical Center. A “massive logistics and supply-chain operation [is] now needed across the country,” says Thomas Inglesby of Johns Hopkins Bloomberg School of Public Health. That can’t be managed by small and inexperienced teams scattered throughout the White House. The solution, he says, is to tag in the Defense Logistics Agency—a 26,000-person group that prepares the U.S. military for overseas operations and that has assisted in past public-health crises, including the 2014 Ebola outbreak.

This agency can also coordinate the second pressing need: a massive rollout of COVID-19 tests. Those tests have been slow to arrive because of five separate shortages: of masks to protect people administering the tests; of nasopharyngeal swabs for collecting viral samples; of extraction kits for pulling the virus’s genetic material out of the samples; of chemical reagents that are part of those kits; and of trained people who can give the tests. Many of these shortages are, again, due to strained supply chains. The U.S. relies on three manufacturers for extraction reagents, providing redundancy in case any of them fails—but all of them failed in the face of unprecedented global demand. Meanwhile, Lombardy, Italy, the hardest-hit place in Europe, houses one of the largest manufacturers of nasopharyngeal swabs.

Read: Why the coronavirus has been so successful

Some shortages are being addressed. The FDA is now moving quickly to approve tests developed by private labs. At least one can deliver results in less than an hour, potentially allowing doctors to know if the patient in front of them has COVID-19. The country “is adding capacity on a daily basis,” says Kelly Wroblewski of the Association of Public Health Laboratories.

On March 6, Trump said that “anyone who wants a test can get a test.” That was (and still is) untrue, and his own officials were quick to correct him. Regardless, anxious people still flooded into hospitals, seeking tests that did not exist. “People wanted to be tested even if they weren’t symptomatic, or if they sat next to someone with a cough,” says Saskia Popescu of George Mason University, who works to prepare hospitals for pandemics. Others just had colds, but doctors still had to use masks to examine them, burning through their already dwindling supplies. “It really stressed the health-care system,” Popescu says. Even now, as capacity expands, tests must be used carefully. The first priority, says Marc Lipsitch of Harvard, is to test health-care workers and hospitalized patients, allowing hospitals to quell any ongoing fires. Only later, once the immediate crisis is slowing, should tests be deployed in a more widespread way. “This isn’t just going to be: Let’s get the tests out there!” Inglesby says.

These measures will take time, during which the pandemic will either accelerate beyond the capacity of the health system or slow to containable levels. Its course—and the nation’s fate—now depends on the third need, which is social distancing. Think of it this way: There are now only two groups of Americans. Group A includes everyone involved in the medical response, whether that’s treating patients, running tests, or manufacturing supplies. Group B includes everyone else, and their job is to buy Group A more time. Group B must now “flatten the curve” by physically isolating themselves from other people to cut off chains of transmission. Given the slow fuse of COVID-19, to forestall the future collapse of the health-care system, these seemingly drastic steps must be taken immediately, before they feel proportionate, and they must continue for several weeks.

Juliette Kayyem: The crisis could last 18 months. Be prepared.

Persuading a country to voluntarily stay at home is not easy, and without clear guidelines from the White House, mayors, governors, and business owners have been forced to take their own steps. Some states have banned large gatherings or closed schools and restaurants. At least 21 have now instituted some form of mandatory quarantine, compelling people to stay at home. And yet many citizens continue to crowd into public spaces.

In these moments, when the good of all hinges on the sacrifices of many, clear coordination matters—the fourth urgent need. The importance of social distancing must be impressed upon a public who must also be reassured and informed. Instead, Trump has repeatedly played down the problem, telling America that “we have it very well under control” when we do not, and that cases were “going to be down to close to zero” when they were rising. In some cases, as with his claims about ubiquitous testing, his misleading gaffes have deepened the crisis. He has even touted unproven medications.

Away from the White House press room, Trump has apparently been listening to Anthony Fauci, the director of the National Institute of Allergy and Infectious Diseases. Fauci has advised every president since Ronald Reagan on new epidemics, and now sits on the COVID-19 task force that meets with Trump roughly every other day. “He’s got his own style, let’s leave it at that,” Fauci told me, “but any kind of recommendation that I have made thus far, the substance of it, he has listened to everything.”

Read: Grocery stores are the coronavirus tipping point

But Trump already seems to be wavering. In recent days, he has signaled that he is prepared to backtrack on social-distancing policies in a bid to protect the economy. Pundits and business leaders have used similar rhetoric, arguing that high-risk people, such as the elderly, could be protected while lower-risk people are allowed to go back to work. Such thinking is seductive, but flawed. It overestimates our ability to assess a person’s risk, and to somehow wall off the ‘high-risk’ people from the rest of society. It underestimates how badly the virus can hit ‘low-risk’ groups, and how thoroughly hospitals will be overwhelmed if even just younger demographics are falling sick.

A recent analysis from the University of Pennsylvania estimated that even if social-distancing measures can reduce infection rates by 95 percent, 960,000 Americans will still need intensive care. There are only about 180,000 ventilators in the U.S. and, more pertinently, only enough respiratory therapists and critical-care staff to safely look after 100,000 ventilated patients. Abandoning social distancing would be foolish. Abandoning it now, when tests and protective equipment are still scarce, would be catastrophic.

Read: America’s hospitals have never experienced anything like this

If Trump stays the course, if Americans adhere to social distancing, if testing can be rolled out, and if enough masks can be produced, there is a chance that the country can still avert the worst predictions about COVID-19, and at least temporarily bring the pandemic under control. No one knows how long that will take, but it won’t be quick. “It could be anywhere from four to six weeks to up to three months,” Fauci said, “but I don’t have great confidence in that range.”

II. The Endgame
Even a perfect response won’t end the pandemic. As long as the virus persists somewhere, there’s a chance that one infected traveler will reignite fresh sparks in countries that have already extinguished their fires. This is already happening in China, Singapore, and other Asian countries that briefly seemed to have the virus under control. Under these conditions, there are three possible endgames: one that’s very unlikely, one that’s very dangerous, and one that’s very long.

The first is that every nation manages to simultaneously bring the virus to heel, as with the original SARS in 2003. Given how widespread the coronavirus pandemic is, and how badly many countries are faring, the odds of worldwide synchronous control seem vanishingly small.

The second is that the virus does what past flu pandemics have done: It burns through the world and leaves behind enough immune survivors that it eventually struggles to find viable hosts. This “herd immunity” scenario would be quick, and thus tempting. But it would also come at a terrible cost: SARS-CoV-2 is more transmissible and fatal than the flu, and it would likely leave behind many millions of corpses and a trail of devastated health systems. The United Kingdom initially seemed to consider this herd-immunity strategy, before backtracking when models revealed the dire consequences. The U.S. now seems to be considering it too.

Read: What will you do if you start coughing?

The third scenario is that the world plays a protracted game of whack-a-mole with the virus, stamping out outbreaks here and there until a vaccine can be produced. This is the best option, but also the longest and most complicated.

It depends, for a start, on making a vaccine. If this were a flu pandemic, that would be easier. The world is experienced at making flu vaccines and does so every year. But there are no existing vaccines for coronaviruses—until now, these viruses seemed to cause diseases that were mild or rare—so researchers must start from scratch. The first steps have been impressively quick. Last Monday, a possible vaccine created by Moderna and the National Institutes of Health went into early clinical testing. That marks a 63-day gap between scientists sequencing the virus’s genes for the first time and doctors injecting a vaccine candidate into a person’s arm. “It’s overwhelmingly the world record,” Fauci said.

But it’s also the fastest step among many subsequent slow ones. The initial trial will simply tell researchers if the vaccine seems safe, and if it can actually mobilize the immune system. Researchers will then need to check that it actually prevents infection from SARS-CoV-2. They’ll need to do animal tests and large-scale trials to ensure that the vaccine doesn’t cause severe side effects. They’ll need to work out what dose is required, how many shots people need, if the vaccine works in elderly people, and if it requires other chemicals to boost its effectiveness.

“Even if it works, they don’t have an easy way to manufacture it at a massive scale,” said Seth Berkley of Gavi. That’s because Moderna is using a new approach to vaccination. Existing vaccines work by providing the body with inactivated or fragmented viruses, allowing the immune system to prep its defenses ahead of time. By contrast, Moderna’s vaccine comprises a sliver of SARS-CoV-2’s genetic material—its RNA. The idea is that the body can use this sliver to build its own viral fragments, which would then form the basis of the immune system’s preparations. This approach works in animals, but is unproven in humans. By contrast, French scientists are trying to modify the existing measles vaccine using fragments of the new coronavirus. “The advantage of that is that if we needed hundreds of doses tomorrow, a lot of plants in the world know how to do it,” Berkley said. No matter which strategy is faster, Berkley and others estimate that it will take 12 to 18 months to develop a proven vaccine, and then longer still to make it, ship it, and inject it into people’s arms.

Read: COVID-19 vaccines are coming, but they’re not what you think

It’s likely, then, that the new coronavirus will be a lingering part of American life for at least a year, if not much longer. If the current round of social-distancing measures works, the pandemic may ebb enough for things to return to a semblance of normalcy. Offices could fill and bars could bustle. Schools could reopen and friends could reunite. But as the status quo returns, so too will the virus. This doesn’t mean that society must be on continuous lockdown until 2022. But “we need to be prepared to do multiple periods of social distancing,” says Stephen Kissler of Harvard.

Much about the coming years, including the frequency, duration, and timing of social upheavals, depends on two properties of the virus, both of which are currently unknown. First: seasonality. Coronaviruses tend to be winter infections that wane or disappear in the summer. That may also be true for SARS-CoV-2, but seasonal variations might not sufficiently slow the virus when it has so many immunologically naive hosts to infect. “Much of the world is waiting anxiously to see what—if anything—the summer does to transmission in the Northern Hemisphere,” says Maia Majumder of Harvard Medical School and Boston Children’s Hospital.

Second: duration of immunity. When people are infected by the milder human coronaviruses that cause cold-like symptoms, they remain immune for less than a year. By contrast, the few who were infected by the original SARS virus, which was far more severe, stayed immune for much longer. Assuming that SARS-CoV-2 lies somewhere in the middle, people who recover from their encounters might be protected for a couple of years. To confirm that, scientists will need to develop accurate serological tests, which look for the antibodies that confer immunity. They’ll also need to confirm that such antibodies actually stop people from catching or spreading the virus. If so, immune citizens can return to work, care for the vulnerable, and anchor the economy during bouts of social distancing.

Scientists can use the periods between those bouts to develop antiviral drugs—although such drugs are rarely panaceas, and come with possible side effects and the risk of resistance. Hospitals can stockpile the necessary supplies. Testing kits can be widely distributed to catch the virus’s return as quickly as possible. There’s no reason that the U.S. should let SARS-CoV-2 catch it unawares again, and thus no reason that social-distancing measures need to be deployed as broadly and heavy-handedly as they now must be. As Aaron E. Carroll and Ashish Jha recently wrote, “We can keep schools and businesses open as much as possible, closing them quickly when suppression fails, then opening them back up again once the infected are identified and isolated. Instead of playing defense, we could play more offense.”

Whether through accumulating herd immunity or the long-awaited arrival of a vaccine, the virus will find spreading explosively more and more difficult. It’s unlikely to disappear entirely. The vaccine may need to be updated as the virus changes, and people may need to get revaccinated on a regular basis, as they currently do for the flu. Models suggest that the virus might simmer around the world, triggering epidemics every few years or so. “But my hope and expectation is that the severity would decline, and there would be less societal upheaval,” Kissler says. In this future, COVID-19 may become like the flu is today—a recurring scourge of winter. Perhaps it will eventually become so mundane that even though a vaccine exists, large swaths of Gen C won’t bother getting it, forgetting how dramatically their world was molded by its absence.

III. The Aftermath
The cost of reaching that point, with as few deaths as possible, will be enormous. As my colleague Annie Lowrey wrote, the economy is experiencing a shock “more sudden and severe than anyone alive has ever experienced.” About one in five people in the United States have lost working hours or jobs. Hotels are empty. Airlines are grounding flights. Restaurants and other small businesses are closing. Inequalities will widen: People with low incomes will be hardest-hit by social-distancing measures, and most likely to have the chronic health conditions that increase their risk of severe infections. Diseases have destabilized cities and societies many times over, “but it hasn’t happened in this country in a very long time, or to quite the extent that we’re seeing now,” says Elena Conis, a historian of medicine at UC Berkeley. “We’re far more urban and metropolitan. We have more people traveling great distances and living far from family and work.”

After infections begin ebbing, a secondary pandemic of mental-health problems will follow. At a moment of profound dread and uncertainty, people are being cut off from soothing human contact. Hugs, handshakes, and other social rituals are now tinged with danger. People with anxiety or obsessive-compulsive disorder are struggling. Elderly people, who are already excluded from much of public life, are being asked to distance themselves even further, deepening their loneliness. Asian people are suffering racist insults, fueled by a president who insists on labeling the new coronavirus the “Chinese virus.” Incidents of domestic violence and child abuse are likely to spike as people are forced to stay in unsafe homes. Children, whose bodies are mostly spared by the virus, may endure mental trauma that stays with them into adulthood.

Read: The kids aren’t all right

After the pandemic, people who recover from COVID-19 might be shunned and stigmatized, as were survivors of Ebola, SARS, and HIV. Health-care workers will take time to heal: One to two years after SARS hit Toronto, people who dealt with the outbreak were still less productive and more likely to be experiencing burnout and post-traumatic stress. People who went through long bouts of quarantine will carry the scars of their experience. “My colleagues in Wuhan note that some people there now refuse to leave their homes and have developed agoraphobia,” says Steven Taylor of the University of British Columbia, who wrote The Psychology of Pandemics.

But “there is also the potential for a much better world after we get through this trauma,” says Richard Danzig of the Center for a New American Security. Already, communities are finding new ways of coming together, even as they must stay apart. Attitudes to health may also change for the better. The rise of HIV and AIDS “completely changed sexual behavior among young people who were coming into sexual maturity at the height of the epidemic,” Conis says. “The use of condoms became normalized. Testing for STDs became mainstream.” Similarly, washing your hands for 20 seconds, a habit that has historically been hard to enshrine even in hospitals, “may be one of those behaviors that we become so accustomed to in the course of this outbreak that we don’t think about them,” Conis adds.

Pandemics can also catalyze social change. People, businesses, and institutions have been remarkably quick to adopt or call for practices that they might once have dragged their heels on, including working from home, conference-calling to accommodate people with disabilities, proper sick leave, and flexible child-care arrangements. “This is the first time in my lifetime that I’ve heard someone say, ‘Oh, if you’re sick, stay home,’” says Adia Benton, an anthropologist at Northwestern University. Perhaps the nation will learn that preparedness isn’t just about masks, vaccines, and tests, but also about fair labor policies and a stable and equal health-care system. Perhaps it will appreciate that health-care workers and public-health specialists compose America’s social immune system, and that this system has been suppressed.

Aspects of America’s identity may need rethinking after COVID-19. Many of the country’s values have seemed to work against it during the pandemic. Its individualism, exceptionalism, and tendency to equate doing whatever you want with an act of resistance meant that when it came time to save lives and stay indoors, some people flocked to bars and clubs. Having internalized years of anti-terrorism messaging following 9/11, Americans resolved to not live in fear. But SARS-CoV-2 has no interest in their terror, only their cells.

Years of isolationist rhetoric had consequences too. Citizens who saw China as a distant, different place, where bats are edible and authoritarianism is acceptable, failed to consider that they would be next or that they wouldn’t be ready. (China’s response to this crisis had its own problems, but that’s for another time.) “People believed the rhetoric that containment would work,” says Wendy Parmet, who studies law and public health at Northeastern University. “We keep them out, and we’ll be okay. When you have a body politic that buys into these ideas of isolationism and ethnonationalism, you’re especially vulnerable when a pandemic hits.”

Graeme Wood: The ‘Chinese virus’ is a test. Don’t fail it.

Veterans of past epidemics have long warned that American society is trapped in a cycle of panic and neglect. After every crisis—anthrax, SARS, flu, Ebola—attention is paid and investments are made. But after short periods of peacetime, memories fade and budgets dwindle. This trend transcends red and blue administrations. When a new normal sets in, the abnormal once again becomes unimaginable. But there is reason to think that COVID-19 might be a disaster that leads to more radical and lasting change.

The other major epidemics of recent decades either barely affected the U.S. (SARS, MERS, Ebola), were milder than expected (H1N1 flu in 2009), or were mostly limited to specific groups of people (Zika, HIV). The COVID-19 pandemic, by contrast, is affecting everyone directly, changing the nature of their everyday life. That distinguishes it not only from other diseases, but also from the other systemic challenges of our time. When an administration prevaricates on climate change, the effects won’t be felt for years, and even then will be hard to parse. It’s different when a president says that everyone can get a test, and one day later, everyone cannot. Pandemics are democratizing experiences. People whose privilege and power would normally shield them from a crisis are facing quarantines, testing positive, and losing loved ones. Senators are falling sick. The consequences of defunding public-health agencies, losing expertise, and stretching hospitals are no longer manifesting as angry opinion pieces, but as faltering lungs.

After 9/11, the world focused on counterterrorism. After COVID-19, attention may shift to public health. Expect to see a spike in funding for virology and vaccinology, a surge in students applying to public-health programs, and more domestic production of medical supplies. Expect pandemics to top the agenda at the United Nations General Assembly. Anthony Fauci is now a household name. “Regular people who think easily about what a policewoman or firefighter does finally get what an epidemiologist does,” says Monica Schoch-Spana, a medical anthropologist at the Johns Hopkins Center for Health Security.

Such changes, in themselves, might protect the world from the next inevitable disease. “The countries that had lived through SARS had a public consciousness about this that allowed them to leap into action,” said Ron Klain, the former Ebola czar. “The most commonly uttered sentence in America at the moment is, ‘I’ve never seen something like this before.’ That wasn’t a sentence anyone in Hong Kong uttered.” For the U.S., and for the world, it’s abundantly, viscerally clear what a pandemic can do.

The lessons that America draws from this experience are hard to predict, especially at a time when online algorithms and partisan broadcasters only serve news that aligns with their audience’s preconceptions. Such dynamics will be pivotal in the coming months, says Ilan Goldenberg, a foreign-policy expert at the Center for a New American Security. “The transitions after World War II or 9/11 were not about a bunch of new ideas,” he says. “The ideas are out there, but the debates will be more acute over the next few months because of the fluidity of the moment and willingness of the American public to accept big, massive changes.”

One could easily conceive of a world in which most of the nation believes that America defeated COVID-19. Despite his many lapses, Trump’s approval rating has surged. Imagine that he succeeds in diverting blame for the crisis to China, casting it as the villain and America as the resilient hero. During the second term of his presidency, the U.S. turns further inward and pulls out of NATO and other international alliances, builds actual and figurative walls, and disinvests in other nations. As Gen C grows up, foreign plagues replace communists and terrorists as the new generational threat.

One could also envisage a future in which America learns a different lesson. A communal spirit, ironically born through social distancing, causes people to turn outward, to neighbors both foreign and domestic. The election of November 2020 becomes a repudiation of “America first” politics. The nation pivots, as it did after World War II, from isolationism to international cooperation. Buoyed by steady investments and an influx of the brightest minds, the health-care workforce surges. Gen C kids write school essays about growing up to be epidemiologists. Public health becomes the centerpiece of foreign policy. The U.S. leads a new global partnership focused on solving challenges like pandemics and climate change.

In 2030, SARS-CoV-3 emerges from nowhere, and is brought to heel within a month.

https://www.theatlantic.com/health/arch ... nd/608719/
ED YONG is a staff writer at The Atlantic, where he covers science.
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Re: Manufactured 'Contagion' - Coronavirus Edition

Postby MacCruiskeen » Wed Mar 25, 2020 8:10 pm

^^ panicmongering timewasting fearporn from the Atlantic. Acres of it.

Talk to supermarket workers instead.
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Re: Manufactured 'Contagion' - Coronavirus Edition

Postby brekin » Wed Mar 25, 2020 11:15 pm

MacCruiskeen » Wed Mar 25, 2020 7:10 pm wrote:^^ panicmongering timewasting fearporn from the Atlantic. Acres of it.
Talk to supermarket workers instead.


Yeah, I always go to Sam the Butcher for the latest scoop on emerging viral pandemics. :roll: X1000

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