Agent Orange Cooper » Sat Jun 09, 2018 3:12 am wrote:https://www.ncbi.nlm.nih.gov/pubmed/23932735
Administration of aluminium to neonatal mice in vaccine-relevant amounts is associated with adverse long term neurological outcomes.
Our previous ecological studies of autism spectrum disorder (ASD) has demonstrated a correlation between increasing ASD rates and aluminium (Al) adjuvants in common use in paediatric vaccines in several Western countries. The correlation between ASD rate and Al adjuvant amounts appears to be dose-dependent and satisfies 8 of 9 Hill criteria for causality. We have now sought to provide an animal model to explore potential behavioural phenotypes and central nervous system (CNS) alterations using s.c. injections of Al hydroxide in early postnatal CD-1 mice of both sexes. Injections of a "high" and "low" Al adjuvant levels were designed to correlate to either the U.S. or Scandinavian paediatric vaccine schedules vs. control saline-injected mice. Both male and female mice in the "high Al" group showed significant weight gains following treatment up to sacrifice at 6 months of age. Male mice in the "high Al" group showed significant changes in light-dark box tests and in various measures of behaviour in an open field. Female mice showed significant changes in the light-dark box at both doses, but no significant changes in open field behaviours. These current data implicate Al injected in early postnatal life in some CNS alterations that may be relevant for a better understanding of the aetiology of ASD.https://www.ncbi.nlm.nih.gov/m/pubmed/21568886/
Aluminum vaccine adjuvants: are they safe?
Aluminum is an experimentally demonstrated neurotoxin and the most commonly used vaccine adjuvant. Despite almost 90 years of widespread use of aluminum adjuvants, medical science's understanding about their mechanisms of action is still remarkably poor. There is also a concerning scarcity of data on toxicology and pharmacokinetics of these compounds. In spite of this, the notion that aluminum in vaccines is safe appears to be widely accepted. Experimental research, however, clearly shows that aluminum adjuvants have a potential to induce serious immunological disorders in humans. In particular, aluminum in adjuvant form carries a risk for autoimmunity, long-term brain inflammation and associated neurological complications and may thus have profound and widespread adverse health consequences. In our opinion, the possibility that vaccine benefits may have been overrated and the risk of potential adverse effects underestimated, has not been rigorously evaluated in the medical and scientific community. We hope that the present paper will provide a framework for a much needed and long overdue assessment of this highly contentious medical issue.https://www.ncbi.nlm.nih.gov/pubmed/19740540
Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration
Gulf War Syndrome is a multi-system disorder afflicting many veterans of Western armies in the 1990-1991 Gulf War. A number of those afflicted may show neurological deficits including various cognitive dysfunctions and motor neuron disease, the latter expression virtually indistinguishable from classical amyotrophic lateral sclerosis (ALS) except for the age of onset. This ALS "cluster" represents the second such ALS cluster described in the literature to date. Possible causes of GWS include several of the adjuvants in the anthrax vaccine and others. The most likely culprit appears to be aluminum hydroxide. In an initial series of experiments, we examined the potential toxicity of aluminum hydroxide in male, outbred CD-1 mice injected subcutaneously in two equivalent-to-human doses. After sacrifice, spinal cord and motor cortex samples were examined by immunohistochemistry. Aluminum-treated mice showed significantly increased apoptosis of motor neurons and increases in reactive astrocytes and microglial proliferation within the spinal cord and cortex. Morin stain detected the presence of aluminum in the cytoplasm of motor neurons with some neurons also testing positive for the presence of hyper-phosphorylated tau protein, a pathological hallmark of various neurological diseases, including Alzheimer's disease and frontotemporal dementia. A second series of experiments was conducted on mice injected with six doses of aluminum hydroxide. Behavioural analyses in these mice revealed significant impairments in a number of motor functions as well as diminished spatial memory capacity. The demonstrated neurotoxicity of aluminum hydroxide and its relative ubiquity as an adjuvant suggest that greater scrutiny by the scientific community is warranted.https://www.ncbi.nlm.nih.gov/pubmed/22235057
Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations
Immune challenges during early development, including those vaccine-induced, can lead to permanent detrimental alterations of the brain and immune function. Experimental evidence also shows that simultaneous administration of as little as two to three immune adjuvants can overcome genetic resistance to autoimmunity. In some developed countries, by the time children are 4 to 6 years old, they will have received a total of 126 antigenic compounds along with high amounts of aluminum (Al) adjuvants through routine vaccinations. According to the US Food and Drug Administration, safety assessments for vaccines have often not included appropriate toxicity studies because vaccines have not been viewed as inherently toxic. Taken together, these observations raise plausible concerns about the overall safety of current childhood vaccination programs. When assessing adjuvant toxicity in children, several key points ought to be considered: (i) infants and children should not be viewed as "small adults" with regard to toxicological risk as their unique physiology makes them much more vulnerable to toxic insults; (ii) in adult humans Al vaccine adjuvants have been linked to a variety of serious autoimmune and inflammatory conditions (i.e., "ASIA"), yet children are regularly exposed to much higher amounts of Al from vaccines than adults; (iii) it is often assumed that peripheral immune responses do not affect brain function. However, it is now clearly established that there is a bidirectional neuro-immune cross-talk that plays crucial roles in immunoregulation as well as brain function. In turn, perturbations of the neuro-immune axis have been demonstrated in many autoimmune diseases encompassed in "ASIA" and are thought to be driven by a hyperactive immune response; and (iv) the same components of the neuro-immune axis that play key roles in brain development and immune function are heavily targeted by Al adjuvants.In summary, research evidence shows that increasing concerns about current vaccination practices may indeed be warranted. Because children may be most at risk of vaccine-induced complications, a rigorous evaluation of the vaccine-related adverse health impacts in the pediatric population is urgently needed.https://www.ncbi.nlm.nih.gov/pubmed/23609067
Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity
We have examined the neurotoxicity of aluminum in humans and animals under various conditions, following different routes of administration, and provide an overview of the various associated disease states. The literature demonstrates clearly negative impacts of aluminum on the nervous system across the age span. In adults, aluminum exposure can lead to apparently age-related neurological deficits resembling Alzheimer's and has been linked to this disease and to the Guamanian variant, ALS-PDC. Similar outcomes have been found in animal models. In addition, injection of aluminum adjuvants in an attempt to model Gulf War syndrome and associated neurological deficits leads to an ALS phenotype in young male mice. In young children, a highly significant correlation exists between the number of pediatric aluminum-adjuvanted vaccines administered and the rate of autism spectrum disorders. Many of the features of aluminum-induced neurotoxicity may arise, in part, from autoimmune reactions, as part of the ASIA syndrome.https://www.ncbi.nlm.nih.gov/pubmed/25428645
Are there negative CNS impacts of aluminum adjuvants used in vaccines and immunotherapy?
In spite of a common view that aluminum (Al) salts are inert and therefore harmless as vaccine adjuvants or in immunotherapy, the reality is quite different. In the following article we briefly review the literature on Al neurotoxicity and the use of Al salts as vaccine adjuvants and consider not only direct toxic actions on the nervous system, but also the potential impact for triggering autoimmunity. Autoimmune and inflammatory responses affecting the CNS appear to underlie some forms of neurological disease, including developmental disorders. Al has been demonstrated to impact the CNS at every level, including by changing gene expression. These outcomes should raise concerns about the increasing use of Al salts as vaccine adjuvants and for the application as more general immune stimulants.https://emedicine.medscape.com/article/165315-overview#a4
Approximately 95% of an aluminum load becomes bound to transferrin and albumin intravascularly and is then eliminated renally. In healthy subjects, only 0.3% of orally administered aluminum is absorbed via the gastrointestinal (GI) tract, and the kidneys effectively eliminate aluminum from the human body. Only when the GI barrier is bypassed, such as by intravenous infusion or in the presence of advanced renal dysfunction, does aluminum have the potential to accumulate. As an example, with intravenously infused aluminum, 40% is retained in adults and up to 75% is retained in neonates. [MY COMMENT: Or in an infant without sufficiently developed myelin sheath—damaged by brain inflammation from prior vaccines, perhaps—where an IM injection bypasses the natural defense of the GI tract and crosses the blood-brain barrier]
...Aluminum is absorbed from the GI tract in the form of oral phosphate-binding agents (aluminum hydroxide), parenterally via immunizations, via dialysate on patients on dialysis or total parenteral nutrition (TPN) contamination, via the urinary mucosa through bladder irrigation, and transdermally in antiperspirants. Lactate, citrate, and ascorbate all facilitate GI absorption.
If a significant aluminum load exceeds the body's excretory capacity, the excess is deposited in various tissues, including bone, brain, liver, heart, spleen, and muscle. This accumulation causes morbidity and mortality through various mechanisms.
Will you look at that. Except for the last one every single one of those papers are written by the same two people, Chris Shaw and Lucija Tomljenovic. That would be the same researchers who have had at least two studies retracted after serious issues with the data was found.
http://www.cbc.ca/news/canada/british-c ... -1.4351855
UBC researchers pull paper linking vaccine component to autism after data alleged to be manipulated
Lab can't confirm allegations because original data is no longer at the university, co-author claims
Rhianna Schmunk · CBC News · Posted: Oct 16, 2017 2:00 AM PT | Last Updated: October 16, 2017
Researchers from the University of British Columbia are retracting their scientific paper linking aluminum in vaccines to autism in mice, because one of the co-authors claims figures published in the study were deliberately altered before publication — an issue he says he realized after allegations of data manipulation surfaced online.
The professor also told CBC News there's no way to know "why" or "how" the figures were allegedly contorted, as he claims original data cited in the study is inaccessible, which would be a contravention of the university's policy around scientific research.
The paper looked at the effects of aluminum components in vaccines on immune response in a mouse's brain. It was published in the Journal of Inorganic Biochemistry on Sept. 5.
Co-authored by Dr. Chris Shaw and Lucija Tomljenovic, it reported aluminum-triggered responses "consistent with those in autism." Shaw said he and Tomljenovic drew their conclusions from data that was "compiled" and "analyzed" for the paper, rather than raw data.
However, subsequent scrutiny has raised questions about the validity of the data, with one doctor calling the paper "anti-vaccine pseudoscience."
The allegations were published last week on Retraction Watch, a site that reports on withdrawn papers as "a window into the scientific process."
By the middle of September, commenters on PubPeer — a database where users can examine and comment on published scientific papers — pointed out that figures in the study appeared to have been altered, and in one case lifted directly from a 2014 study also authored by Shaw and Tomljenovic.
Shaw, a professor at UBC's department of ophthalmology, said he and the lab ran their own analysis of the figures in question after seeing allegations from PubPeer on Sept. 24. He said he requested a retraction from the journal within two days and notified the university.
"It appears as if some of the images in mostly what were non-significant results had been flipped," Shaw told CBC on Thursday. "We don't know why, we don't know how … but there was a screw-up, there's no question about that."
Shaw said the lab can't confirm how the figures were allegedly altered because he claims original data needed for comparison is no longer at the UBC laboratory.
"We don't think that the conclusions are at risk here, but because we don't know, we thought it best to withdraw," the researcher said.
Asked how the seemingly wonky figures weren't caught before publication, Shaw said it was "a good question."
"We were always under the impression that, based on our viewing of the original data a couple years ago and our subsequent analysis of these data, that everything was fine," he said. "One double-checks this at various stages in the process, but by the time you've looked at them enough times and done the various analyses on them, you do tend to believe they're right.
"When you look at these kinds of [data], unless you look at them under very, very high power and magnify them 20 times — which no one does, by the way — you would not necessarily see that there was anything untoward," the professor said.
Original data taken overseas, Shaw claims
Shaw claims the original data is in China, with an analyst who worked on the paper.
The professor claimed the analyst told him the data are "stuck there."
"It's like 'the dog ate my homework.' What are you going to do?"
He noted that, even if the original data are recovered, he thinks "this paper is dead" for credibility reasons.
University policy dictates that original data must remain with the lab for at least five years after it's collected. In this case, the data should stay at the UBC lab until 2018.
The university told CBC it won't be commenting on the retraction or the allegations of removed lab data.
The analyst's lawyer did not comment on the allegations surrounding the data in a statement to CBC, saying it was "a matter between UBC and Dr. Shaw."
Reached by email on Friday, co-author Tomljenovic said she agreed to the retraction but said she "had nothing to do either with collecting or analyzing any of the actual data." She declined further comment.
Alleged data manipulation 'appalling,' expert says
Dr. Michael Gardam, an associate professor of medicine and infectious diseases at the University of Toronto, looked at the paper and the allegations and said there seems to be "pretty clear evidence that data has been falsified" — even if the lab team doesn't have the material to confirm. He called it "appalling."
"I've run [data] like that. They don't change themselves, and the photos don't change themselves," Gardam told CBC on Friday. "The images have been manipulated, according to what I've seen, and I'd argue [Shaw] clearly agrees with that because he's actually retracting the paper."
Past retractions, vaccine documentary
Gardam noted that another scientific paper Shaw worked on on the topic of vaccines was retracted in 2016.
The article, published in the journal Vaccine, questioned the safety of the HPV vaccine Gardasil.
The paper was pulled "due to serious concerns regarding the scientific soundness of the article" and "seriously flawed" methodology, according to the journal.
Shaw was one of the eight co-authors on the study, but he distanced himself from the project on Thursday.
"I was not directly involved except for some editorial comments at the early stages of the manuscript," he said.
The paper was republished by another journal after further review by the authors.
Shaw was also featured in The Greater Good, a 2013 documentary looking at U.S. vaccine programs. The film's website listed the professor as a doctor "with concerns about vaccines."
When it comes to this latest UBC study, Gardam said the university is going to need the original data if it determines an investigation is required.
Shaw said he's likely finished working on papers concerning vaccines after this retraction.
"I'm honestly not sure at this point that I want to dabble in [vaccines] anymore," he said. "We have some projects that are ongoing that have been funded that we feel duty-bound to complete that are on this topic. Frankly, I doubt if I will do it again after that."
CBC also asked the Journal of Inorganic Biochemistry for comment and did not hear back by deadline.
Lucija Tomljenovic also appears to be a fan of Wakefield.
https://www.bmj.com/rapid-response/2011 ... licated--0
The last paper seems to be above board, and does touch on the possible connection (in adults) between macrophagic myofasciitis / chronic fatigue syndrome and some vaccines. There's research being done on it, but so far they haven't been able to determine the cause. It's most likely a genetic predisposition in some individuals that prevents their bodies from disposing of the aluminum properly so it builds up in certain muscles.